Madrid,
04
May
2021
|
10:57
Europe/Amsterdam

Implementation of NPBT in Chicory for Bioactive Terpenes Update

 
CHIC is the Chicory Innovation Consortium. The project's main objectives are 1) to implement New Plant Breeding Techniques (NPBTs) in chicory in order to establish it as a multipurpose crop for the production of health-related products with clear benefits for consumers, and 2) to develop co-innovation pathways with stakeholders for game-changing technologies, such as NPBTs.
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The overall objective of Work Package 3 (WP3) is to explore the potential of laticifers and sesquiterpene lactone biosynthesis for improved or new chicory products. Specific objectives are:

  • • To produce costunolide in chicory root by inactivation of late steps of the terpene biosynthesis pathway
  • • To produce parthenolide in chicory root by cytochrome P450 engineering
  • • To study and modulate the laticifer network of chicory root for optimised terpene storage
  • • To assay the bioactivity of chicory terpenes

Updates

The latex of chicory contains large amounts of sesquiterpene lactones, which interfere with the extraction of inulin. In this work package, one of the objectives is to identify biological activities of interest for these sesquiterpene lactones and to increase their production by using new plant breeding technologies. Bioactivity assays identified one promising sesquiterpene lactone with anti-inflammatory activity and extracts containing antimicrobial activity, for which the responsible substances are being identified. Using transcriptome data and the newly sequenced genome, candidate genes for the biosynthesis of the sesquiterpene lactones and the formation of the laticifers have been identified and are being functionally characterized.

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About CHIC Project

CHIC is the Chicory Innovation Consortium. Its objective is to implement New Plant Breeding Techniques (NPBTs) in chicory in order to establish it as a multipurpose crop for the production of health-related products with clear benefits for consumers and to develop co-innovation pathways with stakeholders for game-changing technologies, such as NPBTs. CHIC will develop four different NPBTs. They will be used to steer bioprocesses in chicory and mobilize its under-explored potential to produce immunomodulatory prebiotics and medicinal terpenes. The conceptually different NPBTs will be assessed with respect to technological potential, risks, regulatory framework, and their socio-economic impacts. This will be done in close consultation with a Stakeholder Advisory Group (SAG) composed of relevant stakeholders in industry and society. For more information, visit our website at chicproject.eu/

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About IDConsortium

IDConsortium is a consultancy firm founded in Seville, Spain, in 2009 with the aim of helping researchers and businesses to internationalise and showcase their R&D by joining international consortiums to pursue different lines of research, development, and innovation. The firm is an offshoot of IDAction S.L., a company with a wide range of experience in managing R&D, innovation, and investment projects. We help promote clusters and sectorial organizations reach their potential at a national and international level. With our experience and involvement in various international innovation projects, we provide strategic advice in the following areas: Industrial Biotechnology, Advanced production systems in Agriculture, Livestock and Aquaculture based on Industry 4.0., and Innovative systems while promoting an active, healthy, and sustainable aging. Visit www.idconsortium.es/ for more information.